Fèvre E M, Barnish G, Yamokgul P, Rooney W
Liverpool School of Tropical Medicine, UK.
Trans R Soc Trop Med Hyg. 1999 Mar-Apr;93(2):180-4. doi: 10.1016/s0035-9203(99)90302-4.
The sensitivity in vitro of Plasmodium falciparum to mefloquine, quinine and artemisinin was assessed in an area of multi-drug resistance on the Thai-Myanmar border, using the World Health Organization's microtest, based on schizont maturation inhibition. Participating individuals were exclusively those who had contracted their infections within Myanmar. A total of 34 successful tests were carried out for mefloquine and quinine, showing a marked decrease in sensitivity compared to previously published results. Ten artemisinin tests were successful, with many failures due to the poor storage stability of the test plates. The implications of the shelf-life of the artemisinin plates is discussed. These results contribute to setting a base line of sensitivity to artemisinin in vitro.
在泰国-缅甸边境多药耐药地区，采用世界卫生组织基于裂殖体成熟抑制的微量试验，评估了恶性疟原虫对甲氟喹、奎宁和青蒿素的体外敏感性。参与试验的个体均为在缅甸感染疟原虫的人。共对甲氟喹和奎宁进行了34次成功试验，结果显示与此前公布的结果相比敏感性显著降低。对青蒿素进行了10次成功试验，由于试验板储存稳定性差，有许多试验失败。文中讨论了青蒿素试验板保质期的影响。这些结果有助于确定青蒿素体外敏感性基线。
