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Structure-based design and synthesis of novel thrombin inhibitors based on phosphinic peptide mimetics.

作者信息

Li M, Lin Z, Johnson M E

机构信息

Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry & Pharmacognosy, University of Illinois at Chicago, 60607-7173, USA.

出版信息

Bioorg Med Chem Lett. 1999 Jul 19;9(14):1957-62. doi: 10.1016/s0960-894x(99)00319-4.

DOI:10.1016/s0960-894x(99)00319-4
PMID:10450962
Abstract

Based on the structure of the thrombin--NAPAP complex, phosphinic dipeptide mimetics were designed as novel thrombin inhibitors. Synthesis and evaluation of these inhibitors revealed a promising lead with an IC50 of 0.6 microM.

摘要

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