抑制剂与凝血酶的结合：X射线晶体学研究 - Suppr

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超能文献

Inhibitor binding to thrombin: x-ray crystallographic studies.

作者信息

Banner D W, Hadváry P

机构信息

Pharmaceutical Research Departments, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

出版信息

Adv Exp Med Biol. 1993;340:27-33. doi: 10.1007/978-1-4899-2418-6_3.

DOI:10.1007/978-1-4899-2418-6_3

PMID:8154341

Abstract

摘要

相似文献

Inhibitor binding to thrombin: x-ray crystallographic studies.抑制剂与凝血酶的结合：X射线晶体学研究

Adv Exp Med Biol. 1993;340:27-33. doi: 10.1007/978-1-4899-2418-6_3.

Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.精制的2.3A 牛凝血酶与基于苯甲脒和精氨酸的凝血酶抑制剂NAPAP、4-TAPAP和MQPA形成的X射线晶体结构。改进抗血栓药物的起点。

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Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.两种新型双功能非底物型凝血酶抑制剂与人α-凝血酶复合物的晶体结构

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pH-dependent binding constants for the inhibition of thrombin by transition state analogs.

Adv Exp Med Biol. 1993;340:67-77. doi: 10.1007/978-1-4899-2418-6_6.

Design, synthesis and biological activity of novel rigid amidino-phenylalanine derivatives as inhibitors of thrombin.新型刚性脒基苯丙氨酸衍生物作为凝血酶抑制剂的设计、合成及生物活性

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The mechanism of binding of low-molecular-weight active site inhibitors to human alpha-thrombin.

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Geometry of binding of the benzamidine- and arginine-based inhibitors N alpha-(2-naphthyl-sulphonyl-glycyl)-DL-p-amidinophenylalanyl-pipe ridine (NAPAP) and (2R,4R)-4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydro-8- quinolinesulphonyl)-L-arginyl]-2-piperidine carboxylic acid (MQPA) to human alpha-thrombin. X-ray crystallographic determination of the NAPAP-trypsin complex and modeling of NAPAP-thrombin and MQPA-thrombin.基于苯甲脒和精氨酸的抑制剂Nα-(2-萘磺酰基-甘氨酰)-DL-对脒基苯丙氨酰哌啶（NAPAP）和(2R,4R)-4-甲基-1-[Nα-(3-甲基-1,2,3,4-四氢-8-喹啉磺酰基)-L-精氨酰]-2-哌啶羧酸（MQPA）与人α-凝血酶结合的几何学。NAPAP-胰蛋白酶复合物的X射线晶体学测定以及NAPAP-凝血酶和MQPA-凝血酶的建模。

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Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.与人类α-凝血酶复合的反向结合肽抑制剂的结构。

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Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I.凝血酶 - 水蛭素复合物形成过程中的静电导向和离子束缚：凝血酶阴离子结合外位点 -I 的作用

Biochemistry. 2001 Apr 24;40(16):4972-9. doi: 10.1021/bi0023549.

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