作为唾液酸酶抑制剂的2,3-不饱和唾液酸类似物的δ4-β-D-吡喃葡萄糖醛酸的合成。
Synthesis of delta4-beta-D-glucopyranosiduronic acids as mimetics of 2,3-unsaturated sialic acids for sialidase inhibition.
作者信息
Florio P, Thomson R J, Alafaci A, Abo S, von Itzstein M
机构信息
Department of Medicinal Chemistry, Monash University (Parkville Campus), Victoria, Australia.
出版信息
Bioorg Med Chem Lett. 1999 Jul 19;9(14):2065-8. doi: 10.1016/s0960-894x(99)00331-5.
Abstract
Mimetics of Neu5Ac2en and KDN2en, based on delta4-beta-delta-glucopyranosiduronic acids, have been synthesised. The Neu5Ac2en mimetic 5 showed inhibition of both bacterial and viral sialidases, with inhibition of the viral sialidase being comparable to that of Neu5Ac2en itself.
摘要
基于δ4-β-δ-吡喃葡萄糖醛酸合成了Neu5Ac2en和KDN2en的模拟物。Neu5Ac2en模拟物5对细菌和病毒唾液酸酶均有抑制作用，对病毒唾液酸酶的抑制作用与Neu5Ac2en本身相当。
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