Liu Z, Li S, Chen J
Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou.
Zhonghua Yan Ke Za Zhi. 1997 Jul;33(4):289-92.
To determine whether herpes simplex virus (HSV) is present in normal cornea.
HSV genome in 22 corneas from donors without the history of herpes simplex keratitis (HSK), 6 positive control corneas from patients with active herpetic keratitis and 6 negative control corneas from embryos was detected by using polymerase chain reaction (PCR).
HSV DNA was present in 20 of 22 normal corneas, and no viral genome was detected in any of the embryonic corneas. All the corneas from patients with active herpetic keratitis showed positive PCR results.
The results indicate that the HSV genome is present in some normal corneas, that is concordant with the seropositive rate of HSV in people.
确定单纯疱疹病毒（HSV）是否存在于正常角膜中。
采用聚合酶链反应（PCR）检测22例无单纯疱疹病毒性角膜炎（HSK）病史供体的角膜、6例活动性疱疹性角膜炎患者的阳性对照角膜和6例胚胎的阴性对照角膜中的HSV基因组。
22例正常角膜中有20例存在HSV DNA，所有胚胎角膜均未检测到病毒基因组。所有活动性疱疹性角膜炎患者的角膜PCR结果均为阳性。
结果表明HSV基因组存在于一些正常角膜中，这与人群中HSV的血清阳性率一致。
