Sun S, He L, Guo Z
Burn Institute of People's Liberation Army, 304th Hospital, Beijing.
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1998 May;14(3):196-8.
To observe influence of escharectomy during and after burn shock stage upon the changes in plasma ET and NO.
35% TBSA full-thickness burn was produced in pigs, which were divided into two groups. Group S was a group undergoing escharectomy during burn shock stage at 24 h postburn. Group C was a group receiving escharectomy at 96 h after injury. ET and NO were determined and ET/NO was calculated.
The levels of ET and NO were higher after injury than before injury in both groups. The level of ET was lower significantly in group S than in group C from 96 h postburn on. The level of NO was higher in group S than in group C. The ET/NO was lower in group S than in group C from PBH 24 on.
Escharectomy during burn shock stage was beneficial in reducing injury of endothelial cells, decreasing exudation and edema, decreasing tissue hypoxia and improving microcirculation.
观察烧伤休克期切痂及伤后切痂对血浆内皮素（ET）和一氧化氮（NO）变化的影响。
制作35%总体表面积全层烧伤的猪模型，分为两组。S组为伤后24小时在烧伤休克期行切痂术的组。C组为伤后96小时行切痂术的组。测定ET和NO并计算ET/NO。
两组伤后ET和NO水平均高于伤前。伤后96小时起，S组ET水平明显低于C组。S组NO水平高于C组。伤后24小时起S组ET/NO低于C组。
烧伤休克期切痂有利于减轻内皮细胞损伤，减少渗出与水肿，减轻组织缺氧，改善微循环。
