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乙酰胆碱处理后神经肌肉接头处的钙利用(作者译)

[Calcium utilization in the neuromuscular junction after acetylcholin treatment (author's transl)].

作者信息

Palánkai G, Sávay G, Poberai M

出版信息

Acta Histochem. 1978;62(2):170-5.

PMID:104523
Abstract

In the site of the myoneural junction a liberation of Ca++ ions, which is similar to that described previously after an electric stimulation or use of cholinesterase inhibitor, can be revealed by histochemical methods (heavy metal substitution, tetracycline fluorescence technique and glyoxal-bis-(2-hydroxyanil) complex formation) using repeated acetylcholine and SCh administration. The possible aspecific reaction due to the presence of Mg++ ions can be excluded by means of the glyoxal-bis(2-hydroxyanil) method. It can be suggested that there is a correlation between the liberation of Ca++ ions an the function dependent mitochondrial energetic processes.

摘要

在肌神经接头部位,通过组织化学方法(重金属替代法、四环素荧光技术和乙二醛双(2-羟基苯胺)复合物形成法),在反复给予乙酰胆碱和琥珀酰胆碱后,可发现钙离子的释放,这与先前电刺激或使用胆碱酯酶抑制剂后所描述的情况类似。乙二醛双(2-羟基苯胺)法可排除由于镁离子存在而可能产生的非特异性反应。可以认为钙离子的释放与功能相关的线粒体能量过程之间存在关联。

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