Ahrendt S A, Sidransky D
Department of Surgery, The Medical College of Wisconsin, Milwaukee, Wisconsin 53326, USA.
Surg Oncol Clin N Am. 1999 Oct;8(4):641-56, vi.
Clonal genetic alterations such as tumor suppressor, gene mutations, or microsatellite instability are a hallmark of human cancer. These genetic alterations can be detected in clinical samples using DNA amplification techniques and used for early detection of cancer. This article reviews molecular-based approaches for screening of malignancies commonly encountered by the practicing general surgeon.
