Ott R A, McCall A R, McHenry C, Jarosz H, Armin A, Lawrence A M, Paloyan E
Am Surg. 1987 Aug;53(8):442-5.
The incidence of thyroid carcinoma in Hashimoto's thyroiditis has been a widely debated issue. Previous authors have reported on this topic by analyzing series of patients with Hashimoto's thyroiditis or patients with thyroid carcinoma, but not both of those populations in the same series. The population consists of a consecutive series of 800 patients operated on for thyroid nodules not associated with a radiation history. Among 161 patients with the diagnosis of thyroid carcinoma, 61 (38%) had coexistent Hashimoto's thyroiditis. In comparison, among 161 sex- and age-matched patients with colloid nodules in the same population, 18 (11%) had Hashimoto's thyroiditis. Furthermore, in the series as a whole, the incidence of Hashimoto's thyroiditis in 423 patients with colloid nodules was 10 per cent. From the perspective of the Hashimoto's thyroiditis population in the same series of 800 thyroidectomies, among 267 patients with Hashimoto's thyroiditis 61 (23%) had coexistent carcinoma. In comparison, among 267 age- and sex-matched patients with colloid nodules there were only ten coexistent carcinomas for an incidence of 4 per cent. The high incidence of carcinoma of the thyroid in Hashimoto's thyroiditis lends credence to the hypothesis that Hashimoto's thyroiditis is a predisposing factor in the development of thyroid carcinoma.
桥本甲状腺炎中甲状腺癌的发病率一直是一个备受争议的问题。以往的作者通过分析桥本甲状腺炎患者系列或甲状腺癌患者系列来报道这一主题，但未在同一系列中同时分析这两类人群。该人群由连续800例因甲状腺结节接受手术且无放疗史的患者组成。在161例诊断为甲状腺癌的患者中，61例（38%）合并有桥本甲状腺炎。相比之下，在同一人群中161例年龄和性别匹配的胶体结节患者中，18例（11%）有桥本甲状腺炎。此外，在整个系列中，423例胶体结节患者中桥本甲状腺炎的发病率为10%。从同一800例甲状腺切除术系列中桥本甲状腺炎人群的角度来看，在267例桥本甲状腺炎患者中，61例（23%）合并有癌症。相比之下，在267例年龄和性别匹配的胶体结节患者中，仅有10例合并癌症，发病率为4%。桥本甲状腺炎中甲状腺癌的高发病率支持了桥本甲状腺炎是甲状腺癌发生的一个易感因素这一假说。
