没有证据表明血清素1Dβ和7受体基因多态性的等位基因与肥胖、体重过轻或神经性厌食症有关。

No evidence for an involvement of alleles of polymorphisms in the serotonin1Dbeta and 7 receptor genes in obesity, underweight or anorexia nervosa.

作者信息

Hinney A, Herrmann H, Löhr T, Rosenkranz K, Ziegler A, Lehmkuhl G, Poustka F, Schmidt M H, Mayer H, Siegfried W, Remschmidt H, Hebebrand J

机构信息

Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Germany.

出版信息

Int J Obes Relat Metab Disord. 1999 Jul;23(7):760-3. doi: 10.1038/sj.ijo.0800926.

DOI:10.1038/sj.ijo.0800926

PMID:10454111

Abstract

The serotonergic (5-hydroxytryptamine, 5-HT) system has been implicated in body weight regulation and in the etiology of anorexia nervosa (AN). Here we describe the screening of the known Phe-124-Cys polymorphism in the 5-HT1Dbeta receptor gene and of the known Pro-279-Leu polymorphism in the 5-HT7 receptor gene. For association tests allele frequencies were compared between up to 393 extremely obese children and adolescents, 142 underweight students and 84 patients with AN. None of the association tests revealed nominal P-values below 0.3. We conclude that a major role of the investigated polymorphisms in body weight regulation or AN appears unlikely.

摘要

血清素能（5-羟色胺，5-HT）系统与体重调节及神经性厌食症（AN）的病因有关。在此，我们描述了对5-HT1Dβ受体基因中已知的Phe-124-Cys多态性以及5-HT7受体基因中已知的Pro-279-Leu多态性的筛查。为进行关联测试，我们比较了多达393名极度肥胖儿童和青少年、142名体重过轻的学生以及84名AN患者之间的等位基因频率。没有一项关联测试显示名义P值低于0.3。我们得出结论，所研究的多态性在体重调节或AN中发挥主要作用的可能性不大。