Meng Ying, Groth Susan W, Hodgkinson Colin A, Mariani Thomas J
School of Nursing University of Rochester Rochester New York USA.
Lab of Neurogenetics Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism Rockville Maryland USA.
Obes Sci Pract. 2021 Mar 27;7(4):441-449. doi: 10.1002/osp4.511. eCollection 2021 Aug.
The importance of the central and peripheral serotonin systems in regulating energy balance and obesity development has been highlighted in animal models. Yet, the role of both serotonin systems has not been systematically assessed in humans. The purpose of this study was to investigate the association of genes within both serotonin systems with obesity outcomes in black adolescents.
African-American adolescents ( = 1052) whose mothers participated the Memphis New Mother's Study were assessed. In total, 110 polymorphisms mapped to 10 serotonin genes were examined for their associations with standardized body mass index (BMI-z) scores and waist circumferences using generalized estimating equation models.
Over 39% of adolescents were overweight or had obesity. Three single nucleotide polymorphisms (SNPs) within , , and , were significantly associated with BMI-z scores ( < 1.7 × 10). Two SNPs in were nominally associated with waist circumferences. One SNP in was associated with BMI-z scores ( = 0.001) and waist circumferences ( = 0.005) only in girls. Tissue-specific expression indicates that three identified genes are predominantly expressed in the brain.
The central serotonin system may play a key role in obesity development in black adolescents. Future studies are warranted to explore additional serotonin system genes and their potential obesogenic mechanisms in humans.
动物模型已凸显中枢和外周5-羟色胺系统在调节能量平衡和肥胖发展中的重要性。然而，这两个5-羟色胺系统在人类中的作用尚未得到系统评估。本研究的目的是调查两个5-羟色胺系统内的基因与黑人青少年肥胖结局之间的关联。
对其母亲参与孟菲斯新母亲研究的非裔美国青少年（n = 1052）进行评估。使用广义估计方程模型，总共检查了映射到10个5-羟色胺基因的110个多态性与标准化体重指数（BMI-z）评分和腰围的关联。
超过39%的青少年超重或肥胖。HTR1B、HTR2A和TPH2内的三个单核苷酸多态性（SNP）与BMI-z评分显著相关（P < 1.7×10⁻⁵）。TPH1中的两个SNP与腰围呈名义上的关联。TPH2中的一个SNP仅在女孩中与BMI-z评分（P = 0.001）和腰围（P = 0.005）相关。组织特异性表达表明，三个已鉴定的基因主要在大脑中表达。
中枢5-羟色胺系统可能在黑人青少年肥胖发展中起关键作用。未来的研究有必要探索更多的5-羟色胺系统基因及其在人类中的潜在致肥胖机制。
