Ricca Valdo, Nacmias Benedetta, Cellini Elena, Di Bernardo Milena, Rotella Carlo Maria, Sorbi Sandro
Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni, 85, 50134 Florence, Italy.
Neurosci Lett. 2002 Apr 26;323(2):105-8. doi: 10.1016/s0304-3940(02)00088-5.
Recent studies have reported a genetic association between the -1438 G/A polymorphism within the promoter region of the 5-HT(2A) receptor gene and eating disorders (ED), with conflicting results. To clarify the role of the -1438 G/A polymorphism in different ED categories we have analyzed the genotype and allele frequency distribution in 54 Italian patients with Binge ED (BED) compared to 132 obese non-BED subjects. No significant differences were found between obese BED and obese non-BED individuals, suggesting that this polymorphism does not genetically distinguish these two phenotypes. Moreover, the evaluation of 148 patients with anorexia nervosa and 86 patients with bulimia nervosa revealed an association of the A allele with both these disorders.
最近的研究报告了5-羟色胺（5-HT）2A受体基因启动子区域内-1438G/A多态性与饮食失调（ED）之间的遗传关联，但结果相互矛盾。为了阐明-1438G/A多态性在不同饮食失调类别中的作用，我们分析了54名患有暴饮暴食型饮食失调（BED）的意大利患者与132名肥胖非BED受试者的基因型和等位基因频率分布。肥胖的BED患者和肥胖的非BED个体之间未发现显著差异，这表明这种多态性在基因上无法区分这两种表型。此外，对148名神经性厌食症患者和86名神经性贪食症患者的评估显示，A等位基因与这两种疾病均有关联。
