Bettinelli A, Basilico E, Metta M G, Borella P, Jaeger P, Bianchetti M G
Second Department of Pediatrics, University of Milan, Italy.
Pediatr Nephrol. 1999 May;13(4):311-4. doi: 10.1007/s004670050615.
The metabolism of potassium and magnesium are closely linked (in situations where potassium and magnesium depletion coexist, magnesium restoration alone is sufficient to correct hypokalemia). Moreover, magnesium deficiency blunts the interplay between circulating calcium and the calciotropic hormones. Renal magnesium wasting, hypokalemia, alkalosis, hypocalciuria, and a tendency towards hypocalcemia characterize Gitelman syndrome. Plasma or intracellular potassium, circulating calcium, and calciotropic hormones were therefore investigated in eight patients (4 females, 4 males, aged 9-20 years) with Gitelman syndrome before and during oral supplementation with magnesium pyrrolidone carboxylate 30 mmol daily for 4 weeks. Magnesium supplementation significantly increased plasma and intracellular magnesium and plasma calcium, but failed to completely restore magnesium deficiency. In contrast, blood levels of parathyroid hormone and calcitriol and plasma and intracellular potassium were not modified following magnesium administration.
钾和镁的代谢密切相关（在钾缺乏和镁缺乏同时存在的情况下，仅补充镁就足以纠正低钾血症）。此外，镁缺乏会削弱循环钙与钙调节激素之间的相互作用。肾性镁消耗、低钾血症、碱中毒、低钙尿症以及倾向于低钙血症是吉特曼综合征的特征。因此，对8例（4例女性，4例男性，年龄9 - 20岁）吉特曼综合征患者在口服每天30 mmol吡咯烷酮羧酸镁4周之前和期间，对血浆或细胞内钾、循环钙和钙调节激素进行了研究。补充镁显著增加了血浆和细胞内镁以及血浆钙，但未能完全纠正镁缺乏。相比之下，补充镁后甲状旁腺激素和骨化三醇的血液水平以及血浆和细胞内钾未发生改变。
