Hertz T, Düllmann J, Nielsen P
Department of Neuroanatomy, and Institute of Physiological Chemistry, Department of Medical Biochemistry, University of Hamburg, FRG.
Acta Anat (Basel). 1992;145(4):378-81. doi: 10.1159/000147393.
In 3,5,5-trimethylhexanoylferrocene-induced iron overload of rats, three different types of iron-loaded macrophages and derivatives thereof were found in the lungs. On the basis of their localization and of their pattern of iron load it was possible to distinguish: (1) Resident macrophages, showing an alveolar localization and a moderate iron content represented by lysosomal ferritin and haemosiderin. (2) Liver-derived macrophages and giant cells, as well as fragments of them. They showed an exclusive localization in capillaries and alveolar septa, and high concentrations of free ferritin molecules in addition to polymorphous ferritin- and haemosiderin-containing siderosomes. (3) Monocyte-derived intravascular pulmonary macrophages. Initially, they contained iron only as lysosomal aggregates of ferritin and haemosiderin, as a result of phagocytosis of liver-derived macrophageal cell fragments. Later in iron overload, they also showed free ferritin molecules in the cytosol and fused intrapulmonarily to giant cells. The resident as well as the liver-derived siderotic pulmonary macrophages provide a way for iron excretion through the airways.
在3,5,5-三甲基己酰基二茂铁诱导的大鼠铁过载模型中，在肺部发现了三种不同类型的铁负载巨噬细胞及其衍生物。根据它们的定位和铁负载模式，可以区分出：（1）驻留巨噬细胞，呈肺泡定位，铁含量中等，以溶酶体铁蛋白和含铁血黄素表示。（2）肝源性巨噬细胞和巨细胞及其碎片。它们仅在毛细血管和肺泡隔中定位，除了含有多形铁蛋白和含铁血黄素的含铁小体之外，还含有高浓度的游离铁蛋白分子。（3）单核细胞衍生的血管内肺巨噬细胞。最初，由于吞噬肝源性巨噬细胞碎片，它们仅含有作为铁蛋白和含铁血黄素溶酶体聚集体的铁。在铁过载后期，它们的细胞质中也出现了游离铁蛋白分子，并在肺内融合形成巨细胞。驻留的以及肝源性含铁肺巨噬细胞为铁通过气道排出提供了一条途径。
