Hausmann K, Wulfhekel U, Düllmann J, Kuse R
Blut. 1976 Apr;32(4):289-95. doi: 10.1007/BF01005312.
1 hour after i. v. infusion of colloidal iron in iron deficient subjects uniform phagosomal iron granules were observed in macrophages and endothelial cells of several organs. 7 to 10 days later transformation into ferritin coould be visualized in macrophages only. Now, these cells showed diffuse iron staining of the cytoplasm due to dispersed ferritin molecules. Polymorphous lysosomes contained densely packed particles from still unchanged ferric hydroxide to paracristalline ferritin. The macrophageal iron was mobilizable in few days to several weeks. The univorm lysosomal iron granules of endothelial cells disappeared after 1 to 2 years. Endothelial iron siderosis without previous i. v. iron application was a frequent finding in pernicious anaemia and iron overload of diverse origin.
在缺铁受试者静脉输注胶体铁1小时后，在多个器官的巨噬细胞和内皮细胞中观察到均匀的吞噬体铁颗粒。7至10天后，仅在巨噬细胞中可观察到向铁蛋白的转化。此时，由于铁蛋白分子分散，这些细胞的细胞质呈现弥漫性铁染色。多形性溶酶体含有从仍未改变的氢氧化铁到准晶体铁蛋白的密集堆积颗粒。巨噬细胞内的铁在数天至数周内可被动员。内皮细胞中均匀的溶酶体铁颗粒在1至2年后消失。在恶性贫血和各种原因引起的铁过载中，经常发现无先前静脉补铁情况下的内皮细胞铁沉着症。
