Angermeyer M C, Boitz K, Löffler W, Müller P, Priebe S
Klinik und Poliklinik für Psychiatrie, Universität Leipzig.
Psychiatr Prax. 1999 Jul;26(4):181-7.
Evaluations of clozapine treatment by relatives of schizophrenic patients were assessed as part of an exploratory study and compared with the patients' own assessment.
46 relatives of individuals suffering from schizophrenia were questioned by means of a problem-centred interview.
In addition to the positive effects on the schizophrenic illness, relatives strikingly often pointed out the calming, sleep-improving effect of clozapine. As opposed to the patients, the majority of relatives were well aware of the risks associated with discontinuing the drug treatment. Both patients and relatives complained about the sedative effect and the increased need for sleep associated with clozapine treatment. However, diverging evaluations were given with regard to hypersalivation, anticholinergic effects, and weight gain. Relatives were more concerned about possible organ damage occurring as a long-term effect than the patients. Further, indications were found that relatives were more worried by the risk of haematotoxic effects resulting from clozapine treatment than the patients. It could be said that, among the relatives, there was a slightly greater awareness of the advantages of clozapine treatment in comparison with conventional neuroleptics than there was with the patients.
The importance of relatives' views in the effort to secure adequate neuroleptic treatment despite the current economic restrictions should not be under-estimated.
作为一项探索性研究的一部分，对精神分裂症患者亲属对氯氮平治疗的评估进行了评价，并与患者自己的评估进行了比较。
通过以问题为中心的访谈对46名精神分裂症患者的亲属进行了询问。
除了对精神分裂症疾病的积极影响外，亲属经常显著指出氯氮平的镇静、改善睡眠的作用。与患者不同，大多数亲属清楚地意识到停止药物治疗相关的风险。患者和亲属都抱怨氯氮平治疗带来的镇静作用和睡眠需求增加。然而，在流涎、抗胆碱能作用和体重增加方面给出了不同的评价。亲属比患者更担心可能作为长期影响出现的器官损害。此外，有迹象表明，亲属比患者更担心氯氮平治疗导致血液毒性作用的风险。可以说，与患者相比，亲属中对氯氮平治疗相对于传统抗精神病药物的优势的认识略高。
在当前经济限制下努力确保充分的抗精神病药物治疗时，亲属观点的重要性不应被低估。
