Lee N H, Lee S W, Choi E H, Lee W S, Ahn S K
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
J Dermatol. 1999 Jul;26(7):465-8. doi: 10.1111/j.1346-8138.1999.tb02028.x.
Pre-Sézary syndrome is an erythroderma with a chronic course, clinical findings of Sézary syndrome, lymphocytic subepidermal band infiltration at times, and repeated cycles of circulating Sézary cells of less than 1,000 cells/mm3. Duration of the pre-existing skin diseases preceding pre-Sézary erythroderma varies from a few weeks to 20 years. Before the erythroderma develops, these patients are diagnosed with contact dermatitis, neurodermatitis, chronic dermatitis, atopic dermatitis, or asteatotic eczema. Hand lesion also precedes the pre-Sézary erythroderma. This condition has been controlled by three cycles of chemotherapy consisting of vincristine, cytoxan, doxorubicin, and prednisolone. We describe a case of pre-Sézary syndrome preceded by hand lesion and treated with chemotherapy.
前塞扎里综合征是一种病程慢性的红皮病，具有塞扎里综合征的临床表现，有时有淋巴细胞表皮下带状浸润，循环塞扎里细胞反复出现且计数低于1000个细胞/mm³。在前塞扎里红皮病之前存在的皮肤病病程从数周至20年不等。在红皮病出现之前，这些患者被诊断为接触性皮炎、神经性皮炎、慢性皮炎、特应性皮炎或乏脂性湿疹。手部病变也先于前塞扎里红皮病出现。该病例通过由长春新碱、环磷酰胺、阿霉素和泼尼松龙组成的三个疗程化疗得到控制。我们描述了一例以手部病变为先兆并接受化疗治疗的前塞扎里综合征病例。
