Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, Poland.
Acta Derm Venereol. 2011 Sep;91(5):574-7. doi: 10.2340/00015555-1149.
We describe here 4 patients with Sézary syndrome masquerading as adult-onset atopic dermatitis. The patients presented with a clinical picture compatible with wide-spread atopic dermatitis and did not fulfil the criteria for Sézary syndrome (lack of lymphoadenopathy and blood involvement, skin histology without presence of atypical cells). In our patients, overt Sézary syndrome developed after immunosuppressive treatment (including cyclosporine). These cases support the validity of the concept of pre-Sézary syndrome, which is a long-lasting, pre-malignant condition, and which may develop to true malignancy in a state of immunosuppression.
我们在此描述了 4 例表现为成人特应性皮炎样的蕈样肉芽肿/ Sézary 综合征患者。这些患者表现出广泛特应性皮炎样的临床表现，不符合 Sézary 综合征的诊断标准（无淋巴结病和血液累及，皮肤组织学未见异型细胞）。在我们的患者中，在接受免疫抑制治疗（包括环孢素）后，出现明显的 Sézary 综合征。这些病例支持了 pre-Sézary 综合征的概念，即一种持久的、恶性前状态，在免疫抑制状态下可能发展为真正的恶性肿瘤。
