局部使用溴莫尼定后婴儿出现明显的中枢神经系统抑制。
Apparent central nervous system depression in infants after the use of topical brimonidine.
作者信息
Carlsen J O, Zabriskie N A, Kwon Y H, Barbe M E, Scott W E
机构信息
John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City 84132, USA.
出版信息
Am J Ophthalmol. 1999 Aug;128(2):255-6. doi: 10.1016/s0002-9394(99)00083-5.
PURPOSE
To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant.
METHODS
Review of two patients. An 11-day-old infant became lethargic and apneic after a single drop of brimonidine. These symptoms were reproduced after a second administration of brimonidine. A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.
RESULTS
The first patient required admission to the hospital for medical stabilization. He recovered without sequelae. The second patient recovered spontaneously approximately 2.5 hours after administration of brimonidine.
CONCLUSIONS
Topical brimonidine may be associated with central nervous system depression in infants. The use of brimonidine is not recommended in these patients until further data are available.
目的
报告两例局部使用溴莫尼定导致婴儿出现明显中枢神经系统抑制和无反应性的病例。
方法
对两名患者进行回顾性分析。一名11天大的婴儿在滴入一滴溴莫尼定后变得嗜睡且呼吸暂停。再次给予溴莫尼定后，这些症状再次出现。一名5个月大的婴儿在每只眼睛滴入一滴溴莫尼定后变得嗜睡且反应迟钝。
结果
第一名患者需要住院进行医学稳定治疗。他康复后无后遗症。第二名患者在使用溴莫尼定后约2.5小时自行康复。
结论
局部使用溴莫尼定可能与婴儿中枢神经系统抑制有关。在获得更多数据之前，不建议在这些患者中使用溴莫尼定。
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