通过磁共振成像监测部分单侧输尿管梗阻大鼠的对侧代偿性肾生长。

Contralateral compensatory kidney growth in rats with partial unilateral ureteral obstruction monitored by magnetic resonance imaging.

作者信息

Wen J G, Ringgaard S, Frøkiaer J, Jørgensen T M, Stødkilde-Jørgensen H, Djurhuus J C

机构信息

Institute of Experimental Clinical Research, Aarhus University, Denmark.

出版信息

J Urol. 1999 Sep;162(3 Pt 2):1084-9. doi: 10.1016/S0022-5347(01)68076-5.

DOI:10.1016/S0022-5347(01)68076-5

PMID:10458437

Abstract

PURPOSE

We studied dynamic changes in total volume and renal vein blood flow in the kidneys contralateral to partial ureteral obstruction induced in newborn rats.

MATERIALS AND METHODS

Using magnetic resonance imaging we investigated changes in total kidney volume and renal vein blood flow in 20 rats with mild and 18 with severe partial ureteral obstruction that was induced on the left side 2 days after birth. A total of 15 sham operated control rats were also studied. Total kidney volume and renal vein blood flow were monitored sequentially every 2 to 6 weeks for a total of 24 weeks. Renal parenchymal volume measured in vivo by magnetic resonance imaging was compared with that measured in vitro at week 24.

RESULTS

Total volume and renal vein blood flow increased significantly in contralateral nonobstructed kidneys from week 14 and thereafter in rats with severe partial unilateral ureteral obstruction. At week 24 volume had increased by 22% and blood flow had increased by 25%. Volume and flow did not increase significantly in contralateral nonobstructed kidneys in rats with mild partial unilateral ureteral obstruction (p = 0.09). Before changes occurred in volume and blood flow in the contralateral nonobstructed kidneys, renal vein blood flow had decreased significantly from week 8 and thereafter in severely obstructed kidneys. In rats with mild partial unilateral ureteral obstruction renal vein blood flow decreased significantly in obstructed kidneys from week 18 and thereafter. Good correlation was noted between MRI in vivo and in vitro kidney volume measurements (r = 0.972, p <0.001).

CONCLUSIONS

A significant increase in total volume and renal vein blood flow in contralateral nonobstructed kidneys did not develop immediately after the onset of detectable functional deterioration in partially obstructed kidneys. Therefore, caution should be used when incorporating compensatory growth into surgical decision making.

摘要

目的

我们研究了新生大鼠单侧输尿管部分梗阻对侧肾脏的总体积和肾静脉血流的动态变化。

材料与方法

采用磁共振成像技术，我们研究了20只轻度和18只重度单侧输尿管部分梗阻大鼠对侧肾脏的总体积和肾静脉血流变化，这些梗阻在出生后2天于左侧诱导产生。另外还研究了15只假手术对照大鼠。每2至6周连续监测总体积和肾静脉血流，共监测24周。将磁共振成像在体测量的肾实质体积与第24周体外测量的体积进行比较。

结果

在重度单侧输尿管部分梗阻的大鼠中，对侧未梗阻肾脏的总体积和肾静脉血流从第14周起显著增加。在第24周时，体积增加了22%，血流增加了25%。在轻度单侧输尿管部分梗阻的大鼠中，对侧未梗阻肾脏的体积和血流没有显著增加（p = 0.09）。在对侧未梗阻肾脏的体积和血流发生变化之前，重度梗阻肾脏的肾静脉血流从第8周起显著下降。在轻度单侧输尿管部分梗阻的大鼠中，梗阻肾脏的肾静脉血流从第18周起显著下降。磁共振成像在体和体外肾脏体积测量之间存在良好的相关性（r = 0.972，p <0.001）。