Orell S R
BreastScreenSA, Wayville, Australia.
Cytopathology. 1999 Aug;10(4):250-8. doi: 10.1046/j.1365-2303.1999.00176.x.
During the first 7.5 years of breast cancer screening in South Australia, 88 radial scar/complex sclerosing lesions were among the mammographically detected abnormalities. A false-positive cytological diagnosis by fine needle biopsy was given in three of 69 such cases with satisfactory smears, a false-positive rate of 4.3% in this particular group. A review of the smears suggested that the false-positive diagnoses could have been avoided if a total or near total absence of a benign epithelial component had been included among the criteria for a malignant diagnosis. However, even after review, atypia was considered sufficiently worrying to be reported as a suspicion of malignancy in 7% of cases.
在南澳大利亚进行乳腺癌筛查的头7.5年里，88例放射状瘢痕/复杂性硬化性病变是在乳房X线检查发现的异常情况中。在69例涂片满意的此类病例中，有3例通过细针穿刺活检得出了假阳性细胞学诊断，该特定组的假阳性率为4.3%。对涂片的审查表明，如果将良性上皮成分完全或几乎完全缺失纳入恶性诊断标准，本可避免假阳性诊断。然而，即便经过审查，在7%的病例中，非典型性仍被认为令人担忧，足以报告为怀疑恶性肿瘤。
