Beason-Held L L, Desmond R E, Herscovitch P, Carson R E
National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
J Cereb Blood Flow Metab. 1999 Aug;19(8):843-52. doi: 10.1097/00004647-199908000-00003.
In positron emission tomography studies using bolus injection of [15O]water, activation responses reflect underlying CBF changes during a short time (15 to 20 seconds) after arrival of the bolus in the brain. This CBF sensitivity window may be too short for complex activation paradigms, however, particularly those of longer duration. To perform such paradigms, we used a slow infusion method of tracer administration to lengthen the CBF sensitivity window. The present study was designed to determine if this slow infusion technique yields similar results to a bolus injection with a short activation task involving memory for faces. When analyzed using statistical parametric mapping, scanning durations of either 90 or 120 seconds and a 90-second slow infusion schedule produced very similar results to a standard 60-second scan collected after bolus injection, indicating that statistically similar brain activation maps can be produced with the two infusion techniques. This slow infusion approach allows for increased flexibility in designing future studies in which a short CBF sensitivity window is a limiting factor.
在使用团注[15O]水的正电子发射断层扫描研究中，激活反应反映了团注到达大脑后短时间内（15至20秒）潜在的脑血流量（CBF）变化。然而，对于复杂的激活范式，尤其是那些持续时间较长的范式，这种CBF敏感性窗口可能太短。为了执行此类范式，我们采用了示踪剂给药的缓慢输注方法来延长CBF敏感性窗口。本研究旨在确定这种缓慢输注技术与涉及面部记忆的短激活任务的团注注射是否产生相似的结果。当使用统计参数映射进行分析时，90秒或120秒的扫描持续时间以及90秒的缓慢输注方案产生的结果与团注注射后收集的标准60秒扫描结果非常相似，这表明两种输注技术可以产生统计学上相似的脑激活图。这种缓慢输注方法在设计未来研究时具有更大的灵活性，在这些研究中，短CBF敏感性窗口是一个限制因素。
