病毒作为自身免疫的触发因素：事实与幻想

Viruses as triggers of autoimmunity: facts and fantasies.

作者信息

Whitton J L, Fujinami R S

机构信息

Department of Neuropharmacology, CVN-9, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA.

出版信息

Curr Opin Microbiol. 1999 Aug;2(4):392-7. doi: 10.1016/s1369-5274(99)80069-1.

DOI:10.1016/s1369-5274(99)80069-1

PMID:10458987

Abstract

Autoimmunity has been proposed as the cause of several human chronic inflammatory diseases, and recent animal studies show that viruses can induce autoimmune disease. These studies demonstrate how viruses might misdirect the immune system, and here we discuss critically the evidence that similar phenomena may lead to human disease.

摘要

自身免疫被认为是几种人类慢性炎症性疾病的病因，最近的动物研究表明病毒可诱发自身免疫性疾病。这些研究揭示了病毒可能如何误导免疫系统，在此我们审慎地讨论类似现象可能导致人类疾病的证据。