抗病毒防御与自身免疫之间的联系。
Connections between antiviral defense and autoimmunity.
作者信息
Stetson Daniel B
机构信息
Department of Immunology, University of Washington, Seattle, WA 98195, USA.
出版信息
Curr Opin Immunol. 2009 Jun;21(3):244-50. doi: 10.1016/j.coi.2009.05.005. Epub 2009 Jun 3.
Abstract
Recent advances have revealed a fundamental contradiction in antiviral immunity: innate immune sensors that detect nucleic acids mediate both protective immunity to infection and pathological autoimmune disease. Thus, the study of the mechanics of nucleic acid detection will provide insight into how these systems are inappropriately triggered in autoimmunity, and, conversely, the study of autoimmune disease triggered by these sensors will tell us more about how they are linked to activation of adaptive immunity.
摘要
近期的进展揭示了抗病毒免疫中的一个基本矛盾
检测核酸的天然免疫传感器既能介导对感染的保护性免疫，也能引发病理性自身免疫疾病。因此，对核酸检测机制的研究将有助于深入了解这些系统在自身免疫中是如何被不恰当激活的，反之，对由这些传感器引发的自身免疫疾病的研究将让我们更多地了解它们与适应性免疫激活之间的联系。
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