Sundstrom P
Department of Medical Microbiology and Immunology, Ohio State University, Columbus, OH 43210-1239, USA.
Curr Opin Microbiol. 1999 Aug;2(4):353-7. doi: 10.1016/S1369-5274(99)80062-9.
The adherent properties of Candida albicans blastoconidia and germ tubes have long been appreciated, but little is known about the mechanisms responsible for adherence. Recently, three genes, ALA1, ALS1 and HWP1, encoding proteins with adherent properties and motifs consistent with linkage to the beta-1, 6-glucan of C. albicans cell walls have provided insight into the topology of protein adhesins. Hwp1, a developmentally regulated adhesin of germ tubes and hyphae, attaches to buccal epithelial cells by an unconventional, transglutaminase-mediated mechanism of adhesion.
白色念珠菌芽生孢子和芽管的黏附特性早已为人所知，但对于其黏附机制却知之甚少。最近，三个基因，即ALA1、ALS1和HWP1，编码具有黏附特性且其基序与白色念珠菌细胞壁β-1,6-葡聚糖相连的蛋白质，这为蛋白质黏附素的拓扑结构提供了见解。Hwp1是一种在芽管和菌丝发育过程中受调控的黏附素，它通过一种非常规的、转谷氨酰胺酶介导的黏附机制附着于口腔上皮细胞。
