Smirniotis V, Kotsis T E, Antoniou S, Kostopanagiotou G, Labrou A, Kourias E, Papadimitriou J
2nd Department of Surgery, Athens University Medical School Aretaeion Hospital, 22 Haniotou Str., Athens, 154 52, Greece.
Clin Nutr. 1999 Apr;18(2):79-81. doi: 10.1016/s0261-5614(99)80055-7.
The relative risk of thrombophlebitis induced by either Long-chain Triglycerides (LCTs) or Medium-chain Triglycerides (MCTs) during peripheral i.v. nutrition (PIN) was evaluated. A total of 76 patients were randomly assigned into group A (n=40) and group B (n=36). The nutritional requirements in both groups were covered by a standardized regime of osmolality 1130 mOsm and pH 5.2, which provided 14 kg/day(-1) nitrogen, 600 kcal/day(-1) of carbohydrates and 1000 kcal/day(-1) of lipids. Group A received the lipids as pure LCTs while group B received a mixture of LCTs/MCTs at a ratio 1:1. The infused nutritional volume was 2000 ml and was delivered via a suitable vein in a proximal forearm, using a fine bore polyurethane 22G catheter. The two standardized regimes were evaluated over a 10 day period regarding the incidence of thrombophlebitis. The cumulative risk of thrombophlebitis was documented to be significantly lower in group A compared to group B (17.5% versus 44.4%, P < 0.05). LCTs appear to prolong peripheral vein feeding by lessening the reaction of venous endothelium to the irritating nutritional infusate.
评估了在外周静脉营养（PIN）期间长链甘油三酯（LCTs）或中链甘油三酯（MCTs）诱发血栓性静脉炎的相对风险。总共76例患者被随机分为A组（n = 40）和B组（n = 36）。两组的营养需求均由渗透压为1130 mOsm、pH值为5.2的标准化方案满足，该方案提供14 kg/天⁻¹的氮、600 kcal/天⁻¹的碳水化合物和1000 kcal/天⁻¹的脂质。A组接受纯LCTs作为脂质，而B组接受LCTs/MCTs比例为1:1的混合物。输注的营养量为2000 ml，通过合适的静脉在前臂近端输送，使用细孔聚氨酯22G导管。在10天的时间内评估两种标准化方案的血栓性静脉炎发生率。记录显示A组血栓性静脉炎的累积风险显著低于B组（17.5%对44.4%，P < 0.05）。LCTs似乎通过减轻静脉内皮对刺激性营养输注液的反应来延长外周静脉喂养时间。
