Barmat L I, Rauch E, Spandorfer S, Kowalik A, Sills E S, Schattman G, Liu H C, Rosenwaks Z
Department of Obstetrics and Gynecology, New York Hospital-Cornell Medical Center, New York, USA.
J Assist Reprod Genet. 1999 Aug;16(7):350-4. doi: 10.1023/a:1020585728549.
Our purpose was to determine if the presence of a hydrosalpinx effects the outcome of in vitro fertilization (IVF)-embryo transfer.
We performed a retrospective analysis of IVF cycle stimulation sheets.
A total of 1000 patients with tubal factor infertility was analyzed. There were 60 hydrosalpinx patients who underwent 116 initiated cycles with 106 embryo transfers, compared to 940 control patients undergoing 1428 initiated cycles with 1150 embryo transfers. Both groups had a similar response to ovarian stimulation, number of oocytes retrieved, and number of embryos transferred. The hydrosalpinx group had a significantly higher preclinical loss rate (22/59 = 37% vs 80/566 = 14%; P = 0.001), a significantly lower implantation rate (55/352 = 16% vs 795/3795 = 21%; P = 0.013), a trend toward a reduced delivery rate per transfer (28/106 = 26% vs 387/1150 = 34%; P = 0.066), a significantly higher ectopic pregnancy rate (5/59 = 8% vs 16/566 = 3%; P = 0.04), and a similar spontaneous abortion rate (9/37 = 24% vs 99/486 = 20%; P = 0.28) compared to the control tubal factor group.
This study demonstrates a decrease in implantation rates and an increase in preclinical miscarriages and ectopic pregnancies in patients with hydrosalpinges compared to tubal-factor patients without sonographic evidence of dilated fallopian tubes.
我们的目的是确定输卵管积水的存在是否会影响体外受精（IVF）-胚胎移植的结果。
我们对IVF周期刺激记录进行了回顾性分析。
共分析了1000例输卵管因素不孕症患者。其中60例输卵管积水患者开始了116个周期，进行了106次胚胎移植，而940例对照患者开始了1428个周期，进行了1150次胚胎移植。两组对卵巢刺激的反应、获取的卵母细胞数量和移植的胚胎数量相似。输卵管积水组的临床前丢失率显著更高（22/59 = 37% 对比80/566 = 14%；P = 0.001），着床率显著更低（55/352 = 16% 对比795/3795 = 21%；P = 0.013），每次移植的分娩率有降低趋势（28/106 = 26% 对比387/1150 = 34%；P = 0.066），异位妊娠率显著更高（5/59 = 8% 对比16/566 = 3%；P = 0.04），与对照输卵管因素组相比，自然流产率相似（9/37 = 24% 对比99/486 = 20%；P = 0.28）。
本研究表明，与无超声证据显示输卵管扩张的输卵管因素患者相比，输卵管积水患者的着床率降低，临床前流产和异位妊娠增加。
