Results of in vitro fertilization and embryo transfer in women with infertility due to genital tuberculosis.

OBJECTIVE

To determine the results of IVF-ET in women with infertility due to genital tuberculosis.

DESIGN

Retrospective case-control study.

SETTING

In vitro fertilization and ET unit of a university hospital.

PATIENTS

Forty-four cycles of IVF-ET were undertaken in 24 women with genital tuberculosis and the results were compared with 366 cycles in 274 nontuberculous tubal factor couples.

INTERVENTIONS

All women with genital tuberculosis were evaluated with hysteroscopy, endometrial biopsy, and acid fast bacilli stain before treatment with IVF-ET.

RESULTS

Subjects with genital tuberculosis had higher basal FSH levels, required more exogenous gonadotropins for controlled ovarian hyperstimulation, reached lower peak E2 levels, and yielded fewer oocytes and embryos when compared with tubal factor patients. Furthermore, in women with genital tuberculosis, clinical pregnancy rate per cycle was lower and spontaneous abortion rate was higher.

CONCLUSIONS

Women with genital tuberculosis appear to represent a less favorable subset within other tubal factor patients when treated with IVF-ET.