Kudo Y, Uchiyama M, Okawa M, Shibui K, Kamei Y, Hayakawa T, Kim K, Ishibashi K
Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Ichikawa-City, Chiba, Japan.
Psychiatry Clin Neurosci. 1999 Apr;53(2):253-5. doi: 10.1046/j.1440-1819.1999.00536.x.
The aim of this study was to clarify effects of hormonal and temperature rhythms on circadian fluctuations of sleep propensity. Ten healthy females underwent 24-h sleep deprivation and entered the circadian sleep propensity assessment setting under the ultra-short sleep-wake schedule. During the experiment, sleep propensity rhythm, rectal temperature, and 24-h serum hormone profiles (melatonin, cortisol and thyroid-stimulating hormone) were investigated. The circadian sleep propensity rhythms had two apparent peaks (afternoon and nocturnal peaks) and a trough (nocturnal sleep gate). The timings of the nocturnal sleep gate and the nocturnal peak were correlated exclusively with temperature and melatonin rhythms (P < 0.05), while that of the afternoon peak was significantly correlated with habitual wake time and melatonin rhythm. These results indicate that the circadian sleep propensity rhythm is influenced not only by the circadian pacemaker, but also by sleep habit.
本研究的目的是阐明激素和温度节律对睡眠倾向昼夜波动的影响。十名健康女性经历了24小时睡眠剥夺，并在超短睡眠-清醒时间表下进入昼夜睡眠倾向评估环境。在实验过程中，研究了睡眠倾向节律、直肠温度和24小时血清激素谱（褪黑素、皮质醇和促甲状腺激素）。昼夜睡眠倾向节律有两个明显的峰值（下午和夜间峰值）和一个谷值（夜间睡眠门）。夜间睡眠门和夜间峰值的时间仅与温度和褪黑素节律相关（P < 0.05），而下午峰值的时间与习惯性清醒时间和褪黑素节律显著相关。这些结果表明，昼夜睡眠倾向节律不仅受昼夜起搏器的影响，还受睡眠习惯的影响。
