Masubuchi S, Hashimoto S, Endo T, Honma S, Honma K
Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Psychiatry Clin Neurosci. 1999 Apr;53(2):249-51. doi: 10.1046/j.1440-1819.1999.00535.x.
The plasma melatonin rhythm was measured longitudinally in a subject with non-24-h sleep-wake syndrome, and the amplitude and area under the curve (AUC) of the melatonin rhythm were investigated in relation to the sleep-wake cycle. When the melatonin rhythm and sleep-wake rhythm were internally desynchronized, the amplitude and the AUC were reduced significantly. These parameters were not influenced by external melatonin administration. These results suggest that a causal relationship between the reduction of circadian oscillation and internal desynchronization exists in this subject.
对一名患有非24小时睡眠-清醒综合征的受试者进行了纵向血浆褪黑素节律测量，并研究了褪黑素节律的振幅和曲线下面积（AUC）与睡眠-清醒周期的关系。当褪黑素节律和睡眠-清醒节律发生内源性不同步时，振幅和AUC显著降低。这些参数不受外源性褪黑素给药的影响。这些结果表明，在该受试者中，昼夜节律振荡减弱与内源性不同步之间存在因果关系。
