疗养院居民尿液分离株的抗菌药物耐药模式。十五年数据回顾。
Antimicrobial resistance patterns in urinary isolates from nursing home residents. Fifteen years of data reviewed.
作者信息
Vromen M, van der Ven A J, Knols A, Stobberingh E E
机构信息
Foundation Nursing Homes SVB, Kerkrade, The Netherlands.
出版信息
J Antimicrob Chemother. 1999 Jul;44(1):113-6. doi: 10.1093/jac/44.1.113.
The antibiotic resistance patterns of gram-negative bacteria isolated from nursing home patients between 1983 and 1997 were analysed. Escherichia coli was the most prevalent isolate (48%) followed by Proteus spp. (26%) and other Enterobacteriaceae (20%). During the study period, the susceptibility of E. coli decreased for co-trimoxazole (79% to 62%), increased for nitrofurantoin (79% to 91%) and remained unchanged for amoxycillin (41%). Susceptibility to norfloxacin, available from 1990, decreased from 87% to 71%. Similar trends were observed when the susceptibilities of all gram-negative urinary pathogens were combined. The changes in susceptibility can probably be attributed to the empirical prescribing practices in the nursing homes studied.
分析了1983年至1997年间从疗养院患者中分离出的革兰氏阴性菌的抗生素耐药模式。大肠埃希菌是最常见的分离菌（48%），其次是变形杆菌属（26%）和其他肠杆菌科细菌（20%）。在研究期间，大肠埃希菌对复方新诺明的敏感性下降（从79%降至62%），对呋喃妥因的敏感性增加（从79%升至91%），对阿莫西林的敏感性保持不变（41%）。1990年开始使用的诺氟沙星的敏感性从87%降至71%。当合并所有革兰氏阴性尿路病原体的敏感性时，观察到类似趋势。敏感性的变化可能归因于所研究疗养院的经验性用药习惯。
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