Giachino F, Allocco A, Tuninetti L, Tullio V, Cuffini A M, Carlone N A
Istituto di Microbiologia, Università di Torino.
G Batteriol Virol Immunol. 1992;85(1-12):55-67.
The in vitro activity of imipenem against 3,496 Gram-negative strains isolated from 4,505 positive urocultures was determined. The effectiveness of imipenem was then compared with that of ampicillin, amoxycillin + clavulanic acid, ticarcillin, piperacillin, aztreonam, cefalotin , ceftazidime, cefoxitin, cefotaxime, norfloxacin, ciprofloxacin, amikacin, gentamicin, tobramycin, trimethoprim + sulfamethoxazole. Imipenem was active against all isolates, including Pseudomonas spp. known to account for a large portion of nosocomial infections and resistance to antibacterial drugs.
测定了亚胺培南对从4505份阳性尿培养物中分离出的3496株革兰氏阴性菌的体外活性。然后将亚胺培南的有效性与氨苄西林、阿莫西林+克拉维酸、替卡西林、哌拉西林、氨曲南、头孢噻吩、头孢他啶、头孢西丁、头孢噻肟、诺氟沙星、环丙沙星、阿米卡星、庆大霉素、妥布霉素、甲氧苄啶+磺胺甲恶唑的有效性进行了比较。亚胺培南对所有分离菌株均有活性，包括已知在医院感染和对抗菌药物耐药中占很大比例的假单胞菌属。
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