Charlton B G
Department of Psychology, University of Newcastle upon Tyne, UK.
Med Hypotheses. 1999 Jun;52(6):609-11. doi: 10.1054/mehy.1999.0857.
It is proposed that electroconvulsive therapy (ECT) is not specifically mood-elevating or anti-depressant but that its effect is as an anti-delirium intervention. I suggest that ECT exerts its primary therapeutic effects by inducing a generalized epileptic seizure which operates on the brain like a deep and restorative sleep that acts rapidly to resolve delirium. Provided that the diagnosis is made using sufficiently sensitive criteria, delirium is here assumed to be a common feature of many so-called 'functional' psychoses - frequently occurring as a consequence of sleep deprivation, and leading to symptoms such as hallucinations, bizarre delusions and psychomotor retardation. Testable predictions of this 'anti-delirium' theory of ECT action are described.
有人提出,电休克疗法(ECT)并非具有特定的情绪提升或抗抑郁作用,其作用是作为一种抗谵妄干预措施。我认为ECT通过诱发全身性癫痫发作发挥其主要治疗作用,这种发作对大脑的作用类似于深度且恢复性的睡眠,能迅速解决谵妄问题。假设诊断采用足够敏感的标准,这里认为谵妄是许多所谓“功能性”精神病的常见特征——常因睡眠剥夺而发生,并导致幻觉、怪异妄想和精神运动迟缓等症状。本文描述了ECT作用的这种“抗谵妄”理论的可检验预测。