Osuna E, García-Víllora A, Pérez-Cárceles M D, Conejero J, Abenza J M, Martínez P, Luna A
Department of Forensic Medicine, University of Murcia, E-30100 Espinardo, Murcia, Spain.
Int J Legal Med. 1999;112(5):275-9. doi: 10.1007/s004140050249.
In clinical practice, biochemical markers, particularly serum glucose levels are used to diagnose diabetes mellitus. However, at autopsy this marker is of no value due to the substantial and capricious fluctuations in glucose levels after death. The aim of this study was to evaluate the usefulness of the postmortem determination of fructosamine in vitreous humor for confirming the presence of antemortem hyperglycemia. This was a study of 92 cadavers with a mean age of 60.05 years (SD 17.73) and a mean postmortem interval of 17.02 h (SD 9.76, range 2-58 h). Cases were assigned to two diagnostic groups according to the antemortem diagnosis of diabetes mellitus based on the patients' medical records. In vitreous humor statistically significant differences were found in glucose and fructosamine concentrations between the two diagnostic groups, the highest values being obtained in the group of subjects with a previous diagnosis of diabetes mellitus.
在临床实践中，生化标志物，尤其是血清葡萄糖水平，被用于诊断糖尿病。然而，在尸检时，由于死后葡萄糖水平存在大幅且多变的波动，该标志物毫无价值。本研究的目的是评估测定死后玻璃体液中果糖胺对于确认生前高血糖症的有用性。这是一项针对92具尸体的研究，这些尸体的平均年龄为60.05岁（标准差17.73），平均死后间隔时间为17.02小时（标准差9.76，范围2 - 58小时）。根据患者病历中生前对糖尿病的诊断，将病例分为两个诊断组。在玻璃体液中，两个诊断组之间的葡萄糖和果糖胺浓度存在统计学上的显著差异，先前诊断为糖尿病的受试者组中获得的值最高。
