Vivero Guillermo, Vivero-Salmerón Guillermo, Pérez Cárceles Maria D, Bedate Andrés, Luna Aurelio, Osuna Eduardo
Department of Biochemistry, University Hospital Virgen Del Rosell, Cartagena, Murcia, Spain.
Rev Diabet Stud. 2008 Winter;5(4):220-4. doi: 10.1900/RDS.2008.5.220. Epub 2009 Feb 10.
In clinical practice, serum glucose levels are used to diagnose diabetes mellitus. In post-mortem diagnosis, however, biochemical markers in vitreous humor are more useful because of the difficulty involved in interpreting blood glucose levels and relatively non-specific pathological features. The aim of this study was to analyze the usefulness of post-mortem determination of glucose and fructosamine combined and to compare the results with those obtained for fructosamine and combined glucose and lactate levels in two diagnostic groups (one diabetic and the other non-diabetic). We studied 377 cadavers (mean age 57.6 yr, SD 20.4, range 15 to 98 yr) with a mean post-mortem interval of 14.9 h. (SD 6.0; range 2 to 24 h). The highest levels were obtained in cases where diabetes mellitus had previously been diagnosed. In relation to diagnostic performance, the most reliable values were those in which glucose and fructosamine were determined jointly. The findings provide information concerning the usefulness of measuring glucose and fructosamine levels as a post-mortem tool for identifying antemortem glycemic control in diabetics.
在临床实践中，血清葡萄糖水平用于诊断糖尿病。然而，在尸检诊断中，由于解释血糖水平存在困难且病理特征相对不特异，玻璃体液中的生化标志物更有用。本研究的目的是分析死后联合测定葡萄糖和果糖胺的有用性，并将结果与两个诊断组（一组糖尿病患者，另一组非糖尿病患者）中果糖胺以及联合测定葡萄糖和乳酸水平所获得的结果进行比较。我们研究了377具尸体（平均年龄57.6岁，标准差20.4，年龄范围15至98岁），平均死后间隔时间为14.9小时（标准差6.0；范围2至24小时）。先前诊断为糖尿病的病例中水平最高。关于诊断性能，最可靠的值是联合测定葡萄糖和果糖胺的值。这些发现提供了有关测量葡萄糖和果糖胺水平作为尸检工具用于识别糖尿病患者生前血糖控制情况的有用性的信息。
