Jilma B, Hergovich N, Stohlawetz P, Eichler H G, Bauer P, Wagner O F
Department of Clinical Pharmacology, TARGET, University Hospital of Vienna, Austria.
Br J Haematol. 1999 Aug;106(2):368-70. doi: 10.1046/j.1365-2141.1999.01543.x.
Glucocorticoids dose-dependently increase plasma levels of granulocyte colony stimulating factor (G-CSF). Based on the marked circadian rhythm of cortisol levels, we hypothesized that plasma levels of G-CSF may also show a diurnal rhythm. A prospective study was conducted in 12 healthy young volunteers. Blood samples were obtained every 2 h over 24 h. G-CSF levels averaged 18.0 ng/l (CI 13. 1-22.9) at 8.00 am, increased continuously and reached peak values at 10.00 p.m. Individual harmonic regression analysis showed a clear circadian rhythm. The individual differences between nadir and peak levels averaged 54% (CI 43-65%). This pronounced diurnal rhythm of G-CSF levels may help understand the circadian changes in circulating stem cells, bone marrow DNA synthesis, or bone marrow toxicity induced by some chemotherapeutic agents.
糖皮质激素可使粒细胞集落刺激因子（G-CSF）的血浆水平呈剂量依赖性升高。基于皮质醇水平明显的昼夜节律，我们推测G-CSF的血浆水平可能也呈现昼夜节律。对12名健康年轻志愿者进行了一项前瞻性研究。在24小时内每2小时采集一次血样。上午8点时，G-CSF水平平均为18.0纳克/升（可信区间为13.1 - 22.9），随后持续升高，在晚上10点达到峰值。个体谐波回归分析显示出明显的昼夜节律。最低点与峰值水平之间的个体差异平均为54%（可信区间为43 - 65%）。G-CSF水平这种明显的昼夜节律可能有助于理解循环干细胞、骨髓DNA合成或某些化疗药物引起的骨髓毒性的昼夜变化。
