Bergenfeldt M, Svensson P J, Borgström A
Department of Surgery, University Hospital of Malmö, Sweden.
Br J Surg. 1999 Aug;86(8):1059-62. doi: 10.1046/j.1365-2168.1999.01194.x.
Mesenteric venous thrombosis is a rare cause of acute abdominal pain that may be the result of coagulation abnormalities.
Four consecutive patients with mesenteric venous thrombosis underwent haematological evaluation.
All four had activated protein C resistance resulting from a single mutation in the gene coding for coagulation factor V. Three had surgery; in one patient the diagnosis was made by ultrasonography. One of the patients who had surgery died but the other three survived and were treated with long-term anticoagulation.
Activated protein C resistance may be an important pathogenetic factor in primary mesen-teric vein thrombosis.
肠系膜静脉血栓形成是急性腹痛的罕见病因，可能是凝血异常的结果。
对连续4例肠系膜静脉血栓形成患者进行血液学评估。
所有4例患者均因凝血因子V编码基因的单一突变导致活化蛋白C抵抗。3例接受了手术；1例患者通过超声检查确诊。1例接受手术的患者死亡，但其他3例存活并接受了长期抗凝治疗。
活化蛋白C抵抗可能是原发性肠系膜静脉血栓形成的重要致病因素。
