甲基正戊基酮神经毒性的电诊断研究
An electrodiagnostic study of the neurotoxicity of methyl n-amyl ketone.
作者信息
Johnson B L, Setzer J V, Lewis T R, Hornung R W
出版信息
Am Ind Hyg Assoc J. 1978 Nov;39(11):866-72. doi: 10.1080/0002889778507876.
The neurotoxicity of methyl n-amyl ketone was investigated in a chronic inhalation study lasting 9 months. Rats and monkeys were exposed 6 hrs/day, 5 days/week, to mean MAK levels of 0, 131, and 1025 ppm. Electrodiagnostic measures of nervous system function revealed no neurotoxic impairment at either MAK exposure. Body weights were similarly unaffected. Gross and histopathology also indicated no adverse effects of MAK. It was concluded that MAK does not possess neurotoxic properties similar to those possessed by methyl n-butyl ketone.
在一项为期9个月的慢性吸入研究中，对甲基正戊基酮的神经毒性进行了研究。大鼠和猴子每天暴露6小时，每周暴露5天，平均甲基正戊基酮水平分别为0、131和1025 ppm。神经系统功能的电诊断测量结果显示，在任何甲基正戊基酮暴露水平下均未出现神经毒性损伤。体重也同样未受影响。大体病理学和组织病理学检查也表明甲基正戊基酮没有不良影响。研究得出结论，甲基正戊基酮不具有与甲基正丁基酮类似的神经毒性特性。
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