Misumi J, Nagano M
Br J Ind Med. 1985 Mar;42(3):155-61. doi: 10.1136/oem.42.3.155.
The neurotoxicity of methyl n-butyl ketone is known to be enhanced by combination with methyl ethyl ketone. This study was conducted to clarify the potentiating effect of aliphatic monoketones on the neurotoxicity of methyl n-butyl ketone. Rats were subcutaneously injected in the back with 4 mmol/kg/day of methyl ethyl ketone, methyl n-propyl ketone, methyl n-amyl ketone, or methyl n-hexyl ketone mixed with an equimolar dose of methyl n-butyl ketone five days a week for 20 weeks. The maximum motor fibre conduction velocity and the distal latency were measured every two weeks in the tail nerves of the treated animals and controls. All the monoketones tested enhanced the neurotoxicity of methyl n-butyl ketone. Of the compounds tested, methyl n-hexyl ketone, which had the longest carbon chain, enhanced the neurotoxicity of methyl n-butyl ketone most strongly. These results suggest that the length of the carbon chain of the aliphatic monoketones combined with methyl n-butyl ketone was related to the enhancement of the neurotoxicity of the neurotoxic compound.
已知甲基正丁基酮与甲乙酮合用时神经毒性会增强。本研究旨在阐明脂肪族单酮对甲基正丁基酮神经毒性的增强作用。将大鼠背部皮下注射4 mmol/kg/天的甲乙酮、甲基正丙基酮、甲基正戊基酮或甲基正己基酮，这些物质均与等摩尔剂量的甲基正丁基酮混合，每周五天，持续20周。每两周测量一次受试动物和对照动物尾神经的最大运动纤维传导速度和远端潜伏期。所有测试的单酮均增强了甲基正丁基酮的神经毒性。在测试的化合物中，碳链最长的甲基正己基酮对甲基正丁基酮神经毒性的增强作用最强。这些结果表明，与甲基正丁基酮结合的脂肪族单酮的碳链长度与神经毒性化合物神经毒性的增强有关。
