Turnbull P C, Kramer J M, Jørgensen K, Gilbert R J, Melling J
Am J Clin Nutr. 1979 Jan;32(1):219-28. doi: 10.1093/ajcn/32.1.219.
Evidence is provided that the enterotoxin of Bacillus cereus variously described in the literature as diarrheagenic toxin, diarrheal agent, fluid accumulation factor, vascular permeability factor, dermonecrotic toxin, and intestinonecrotic toxin is a single relatively unstable protein of molecular weight approximately 50,000 and isoelectric point of the order of 4.9. It is presumed to be the enterotoxin responsible for the diarrheal-type B. cereus food poisoning syndrome and it may also be the pyogenic and pyrogenic factor in nongastrointestinal B. cereus infections of man and animals. The enterotoxin is a vegetative growth metabolite produced to one degree or another by almost all B. cereus strains and is readily separated from phospholipase and heat-labile cereolysin but less readily differentiated from a heat-stable hemolysin. It is lethal to mice but may also be separable from another mouse lethal factor by electrofocusing. The emetic toxin responsible for the vomiting-type B. cereus food poisoning syndrome is clearly distinguishable from the diarrheal and other toxic factors and appears to be a highly stable compound of molecular size less than 5000.
有证据表明，蜡样芽孢杆菌的肠毒素在文献中被描述为致腹泻毒素、腹泻因子、液体蓄积因子、血管通透性因子、皮肤坏死毒素和肠坏死毒素，它是一种分子量约为50,000、等电点约为4.9的单一相对不稳定蛋白质。推测它是导致蜡样芽孢杆菌腹泻型食物中毒综合征的肠毒素，它也可能是人和动物非胃肠道蜡样芽孢杆菌感染中的化脓和致热因子。肠毒素是几乎所有蜡样芽孢杆菌菌株在一定程度上产生的一种营养生长代谢产物，很容易与磷脂酶和热不稳定的蜡样芽孢杆菌溶血素分离，但与热稳定溶血素较难区分。它对小鼠具有致死性，但也可通过电聚焦与另一种小鼠致死因子分离。导致蜡样芽孢杆菌呕吐型食物中毒综合征的催吐毒素与腹泻及其他毒素因子明显不同，似乎是一种分子大小小于5000的高度稳定化合物。
