Cheema G S, Quismorio F P
Department of Medicine, University of Southern California, Los Angeles 90033, USA.
Curr Opin Pulm Med. 1999 Sep;5(5):305-9. doi: 10.1097/00063198-199909000-00007.
Adult-onset Still's disease (AOSD) is a rare splenic disorder with an unknown cause. It is not uncommon for AOSD to involve other organs, such as the liver; the kidney; the bone marrow; and, less often, the lungs. In this review, we discuss the pulmonary complications of AOSD. Pulmonary involvement in AOSD usually consists of pleural effusion or transient pulmonary infiltrates, but it may become life threatening if it progresses to the adult respiratory distress syndrome. Chronic conditions, such as restrictive lung disease, have also been reported in patients with AOSD. The only treatment currently available is high-dose steroids, although other agents, such as intravenous immunoglobulin, cyclophosphamide, and azathioprine, have been tried with some success.
成人斯蒂尔病（AOSD）是一种病因不明的罕见脾脏疾病。AOSD累及其他器官并不罕见，如肝脏、肾脏、骨髓，较少累及肺部。在本综述中，我们讨论AOSD的肺部并发症。AOSD的肺部受累通常包括胸腔积液或短暂性肺部浸润，但如果进展为成人呼吸窘迫综合征则可能危及生命。AOSD患者中也有诸如限制性肺病等慢性病的报道。目前唯一可用的治疗方法是大剂量类固醇，尽管也曾尝试使用其他药物，如静脉注射免疫球蛋白、环磷酰胺和硫唑嘌呤，且取得了一定成功。
