Katulski K, Warenik-Szymankiewicz A, Trzeciak W H
Katedry i Zakładu Chemii Fizjologicznej AM im. K. Marcinkowskiego w Poznaniu.
Ginekol Pol. 1999 May;70(5):315-22.
Ovarian androgens constitute substrates for estrogen formation, the key enzyme in androgen production being 17 alpha-hydroxylase/17,20 lyase, while in estrogen synthesis, aromatase. Both enzymes are constituents of a complex, comprising two proteins: cytochrome P450 reductase and respective cytochromes P450c17 or P450arom, whose expression play an important role in a proper function of the ovaries and its genetically determined abnormalities may lead to appearance of clinical symptoms. Although it is difficult to clearly define the genetic background of disturbances, leading to hyperandrogenism, metabolic abnormalities, resulting in excessive androgen production, were observed in polycystic ovarian syndrome, hyperthecosis and hyperinsulinemia. In this review data from literature were presented and discussed regarding endocrine and molecular background of hyperandrogenism of ovarian origin.
卵巢雄激素是雌激素形成的底物，雄激素产生的关键酶是17α-羟化酶/17,20裂解酶，而在雌激素合成中，关键酶是芳香化酶。这两种酶都是一个复合物的组成部分，该复合物由两种蛋白质组成：细胞色素P450还原酶和各自的细胞色素P450c17或P450arom，它们的表达对卵巢的正常功能起着重要作用，其基因决定的异常可能导致临床症状的出现。虽然很难明确导致高雄激素血症的紊乱的遗传背景，但在多囊卵巢综合征、卵泡膜细胞增殖症和高胰岛素血症中观察到了导致雄激素产生过多的代谢异常。在这篇综述中，我们展示并讨论了来自文献的关于卵巢源性高雄激素血症的内分泌和分子背景的数据。
