雄激素受体基因中较短的CAG重复序列可能会增强多囊卵巢综合征中的高雄激素血症。
Shorter CAG repeats in the androgen receptor gene may enhance hyperandrogenicity in polycystic ovary syndrome.
作者信息
Van Nieuwerburgh Filip, Stoop Dominic, Cabri Patrick, Dhont Marc, Deforce Dieter, De Sutter Petra
机构信息
Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.
出版信息
Gynecol Endocrinol. 2008 Dec;24(12):669-73. doi: 10.1080/09513590802342841.
BACKGROUND
The main goal of the present study was to assess the influence of the androgen receptor gene CAG repeat polymorphism on hyperandrogenism and its phenotypical features in patients with polycystic ovary syndrome (PCOS).
METHODS
CAG repeat lengths were analyzed in 97 oligo-anovulatory women with ultrasound features of PCOS. All individuals were assessed for endocrine parameters and their phenotypical features were recorded. These parameters were correlated with the CAG repeat lengths.
RESULTS
PCOS patients with a bi-allelic mean lower than 21 repeats had lower dihydrotestosterone levels (p = 0.007), lower androstenedione levels (p = 0.023), lower luteinizing hormone levels (p = 0.023), a lower luteinizing hormone/follicle-stimulating hormone ratio (p = 0.021) and the highest percentage of patients with acne and/or hirsutism (p = 0.021).
CONCLUSIONS
Our findings support the hypothesis that the PCOS phenotype may result from either elevated androgen levels or an enhanced sensitivity to androgens caused by a more active androgen receptor.
背景
本研究的主要目的是评估雄激素受体基因CAG重复多态性对多囊卵巢综合征（PCOS）患者高雄激素血症及其表型特征的影响。
方法
分析了97名具有PCOS超声特征的少排卵女性的CAG重复长度。对所有个体进行内分泌参数评估，并记录其表型特征。将这些参数与CAG重复长度进行关联分析。
结果
双等位基因平均重复次数低于21次的PCOS患者，其双氢睾酮水平较低（p = 0.007），雄烯二酮水平较低（p = 0.023），黄体生成素水平较低（p = 0.023），黄体生成素/卵泡刺激素比值较低（p = 0.021），痤疮和/或多毛症患者的比例最高（p = 0.021）。
结论
我们的研究结果支持以下假设：PCOS表型可能是由于雄激素水平升高或雄激素受体活性增强导致对雄激素敏感性增加所致。
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