Zielińska M, Selmaj K
Kliniki Neurologii AM w Lodzi.
Neurol Neurochir Pol. 1998 Sep-Oct;32(5):1273-80.
We present a case of 47-year old patient with a rare form of focal dystonia restricted to laryngeal adductors with blepharospasm. Apart from typical symptoms of blepharospasm, the patient had severe problems with articulation in the form of harsh voice, frequently interrupted speech and the sound coming out with a great effort. We applied a transcutaneous botulin toxin therapy to this patient. The toxin was given into thyroarytenoid muscle in transcutaneous injections under control of EMG. Successful clinical effect was achieved with the dose of 80 U of the botulin toxin (Dysport) and lasted 6 months. The treatment was repeated, and the patient has not presented the symptoms of the disease since then for 10 months. We confirm that the botuline toxin transcutaneous injections represent a save and effective treatment for laryngeal adductor dystonia.
我们报告一例47岁患者，患有罕见的局限性肌张力障碍，仅累及喉内收肌并伴有眼睑痉挛。除了眼睑痉挛的典型症状外，患者还存在严重的发音问题，表现为声音粗糙、讲话频繁中断且发声费力。我们对该患者采用了经皮肉毒毒素疗法。在肌电图监测下，将毒素经皮注射到甲杓肌。80单位的肉毒毒素（Dysport）剂量取得了成功的临床效果，且持续了6个月。之后重复进行了治疗，自那时起10个月来患者未再出现该疾病的症状。我们证实，经皮注射肉毒毒素是治疗喉内收肌肌张力障碍安全有效的方法。
