Loven J O, Brøndbo K, Ganes T
Ore-nese-halsavdelingen Rikshospitalet, Oslo.
Tidsskr Nor Laegeforen. 1993 Mar 10;113(7):841-3.
Laryngeal dystonia is a condition characterized by involuntary spasms of the laryngeal muscles. In most patients this involves the adductor laryngeal muscles (adductor laryngeal dystonia). Treatment with a variety of therapies, including speech therapy and pharmacotherapy, have led to minimal improvement. Injections of botulinum-toxin (Botox) bilaterally into the vocalis muscles is a new treatment for adductor laryngeal dystonia. Since May 1991 we have treated 23 patients with adductor laryngeal dystonia with botulinum-toxin. In 74% of the patients the voice improved within 24-72 hours, and effect lasted for 2-14 months (average four months). Most of the patients got a breathy voice and a mild sensation of dysphagia during the first week after the injection.
喉肌张力障碍是一种以喉部肌肉不自主痉挛为特征的病症。在大多数患者中，这涉及喉内收肌（内收型喉肌张力障碍）。包括言语治疗和药物治疗在内的多种治疗方法收效甚微。双侧声带肌注射肉毒杆菌毒素（保妥适）是治疗内收型喉肌张力障碍的一种新方法。自1991年5月以来，我们用肉毒杆菌毒素治疗了23例内收型喉肌张力障碍患者。74%的患者在24至72小时内声音改善，效果持续2至14个月（平均四个月）。大多数患者在注射后的第一周出现声音带呼吸声和轻度吞咽困难感。
