North C S, Nixon S J, Shariat S, Mallonee S, McMillen J C, Spitznagel E L, Smith E M
School of Medicine, Department of Psychiatry, Washington University, St Louis, MO 63110, USA.
JAMA. 1999 Aug 25;282(8):755-62. doi: 10.1001/jama.282.8.755.
Disasters expose unselected populations to traumatic events and can be used to study the mental health effects. The Oklahoma City, Okla, bombing is particularly significant for the study of mental health sequelae of trauma because its extreme magnitude and scope have been predicted to render profound psychiatric effects on survivors.
To measure the psychiatric impact of the bombing of the Alfred P. Murrah Federal Building in Oklahoma City on survivors of the direct blast, specifically examining rates of posttraumatic stress disorder (PTSD), diagnostic comorbidity, functional impairment, and predictors of postdisaster psychopathology.
DESIGN, SETTING, AND PARTICIPANTS: Of 255 eligible adult survivors selected from a confidential registry, 182 (71%) were assessed systematically by interviews approximately 6 months after the disaster, between August and December 1995.
Diagnosis of 8 psychiatric disorders, demographic data, level of functioning, treatment, exposure to the event, involvement of family and friends, and physical injuries, as ascertained by the Diagnostic Interview Schedule/Disaster Supplement.
Forty-five percent of the subjects had a postdisaster psychiatric disorder and 34.3% had PTSD. Predictors included disaster exposure, female sex (for any postdisaster diagnosis, 55% vs 34% for men; chi2 = 8.27; P=.004), and predisaster psychiatric disorder (for PTSD, 45% vs 26% for those without predisaster disorder; chi2 = 6.86; P=.009). Onset of PTSD was swift, with 76% reporting same-day onset. The relatively uncommon avoidance and numbing symptoms virtually dictated the diagnosis of PTSD (94% meeting avoidance and numbing criteria had full PTSD diagnosis) and were further associated with psychiatric comorbidity, functional impairment, and treatment received. Intrusive reexperience and hyperarousal symptoms were nearly universal, but by themselves were generally unassociated with other psychopathology or impairment in functioning.
Our data suggest that a focus on avoidance and numbing symptoms could have provided an effective screening procedure for PTSD and could have identified most psychiatric cases early in the acute postdisaster period. Psychiatric comorbidity further identified those with functional disability and treatment need. The nearly universal yet distressing intrusive reexperience and hyperarousal symptoms in the majority of nonpsychiatrically ill persons may be addressed by nonmedical interventions of reassurance and support.
灾难使未经过挑选的人群暴露于创伤性事件中,可用于研究对心理健康的影响。俄克拉何马城爆炸案对于创伤后心理健康后遗症的研究尤为重要,因为其规模和范围极大,预计会对幸存者产生深远的精神影响。
评估俄克拉何马城阿尔弗雷德·P·默拉联邦大楼爆炸案对直接爆炸幸存者的精神影响,具体研究创伤后应激障碍(PTSD)的发生率、诊断合并症、功能损害以及灾后精神病理学的预测因素。
设计、地点和参与者:从一个保密登记册中选取的255名符合条件的成年幸存者中,182人(71%)在1995年8月至12月灾难发生后约6个月接受了系统访谈评估。
通过诊断性访谈表/灾难补充版确定8种精神障碍的诊断、人口统计学数据、功能水平、治疗情况、事件暴露情况、家人和朋友的参与情况以及身体损伤情况。
45%的受试者患有灾后精神障碍,34.3%患有PTSD。预测因素包括灾难暴露、女性(对于任何灾后诊断,女性为55%,男性为34%;χ² = 8.27;P = 0.004)以及灾前精神障碍(对于PTSD,有灾前精神障碍者为45%,无灾前精神障碍者为26%;χ² = 6.86;P = 0.009)。PTSD发病迅速,76%的人报告当天发病。相对不常见的回避和麻木症状实际上决定了PTSD的诊断(94%符合回避和麻木标准的人被诊断为完全PTSD),并且与精神合并症、功能损害和接受的治疗进一步相关。闯入性再体验和过度警觉症状几乎普遍存在,但就其本身而言,通常与其他精神病理学或功能损害无关。
我们的数据表明,关注回避和麻木症状可以为PTSD提供一种有效的筛查程序,并且可以在灾后急性期早期识别出大多数精神病例。精神合并症进一步确定了那些有功能残疾和治疗需求的人。大多数非精神疾病患者中几乎普遍存在但令人痛苦的闯入性再体验和过度警觉症状,可以通过安慰和支持等非医疗干预措施来解决。