Sakatani K, Chen S, Lichty W, Zuo H, Wang Y P
Department of Neurosurgery, China-Japan Friendship Hospital, Hepingli, Beijing, People's Republic of China.
Early Hum Dev. 1999 Jul;55(3):229-36. doi: 10.1016/s0378-3782(99)00019-5.
Recent neuronal activation studies on newborns using functional MRI or near infrared spectroscopy (NIRS) have suggested that the increase in O2 consumption accompanying neuronal activation exceeds the increase in O2 delivery in the visual cortex during photic stimulation. In the present study, we evaluated the cerebral blood oxygenation (CBO) changes induced by auditory stimulation in the frontal lobe of newborns using NIRS. We studied 28 newborns; the postnatal age at CBO measurements was 3.1+/-0.3 days (mean+/-S.E.M.). We measured concentration changes of deoxyhemoglobin (Deoxy-Hb), oxyhemoglobin (Oxy-Hb), and total hemoglobin (Total-Hb) induced by auditory (music) stimulation in the bilateral frontal lobes of the newborns. Twenty-six (92.9%) out of 28 subjects showed increases of Oxy-Hb and Total-Hb during the stimulation. In these subjects, 17 (60.7%) subjects showed an increase of Deoxy-Hb associated with increases of Oxy-Hb and Total-Hb, while nine (32.1%) subjects showed a decrease of Deoxy-Hb. Although the direction of the Deoxy-Hb differed, these two groups did not differ for Oxy-Hb and Total-Hb (P > 0.05). Two (7.1%) subjects showed other changes. The frontal lobe of newborns shows CBO responses similar to those observed in the visual cortex, specifically neuronal activation causes an increase of Deoxy-Hb associated with increases of Oxy-Hb and Total-Hb. These results support the hypothesis that increments in O2 consumption exceed increments in O2 delivery during neuronal activity in newborns.
近期利用功能磁共振成像（functional MRI）或近红外光谱技术（NIRS）对新生儿进行的神经元激活研究表明，在光刺激期间，视觉皮层中伴随神经元激活的氧气消耗增加超过了氧气输送的增加。在本研究中，我们使用NIRS评估了新生儿额叶听觉刺激引起的脑血氧合（CBO）变化。我们研究了28名新生儿；进行CBO测量时的出生后年龄为3.1±0.3天（平均值±标准误）。我们测量了新生儿双侧额叶听觉（音乐）刺激引起的脱氧血红蛋白（Deoxy-Hb）、氧合血红蛋白（Oxy-Hb）和总血红蛋白（Total-Hb）的浓度变化。28名受试者中有26名（92.9%）在刺激期间显示Oxy-Hb和Total-Hb增加。在这些受试者中，17名（60.7%）受试者显示Deoxy-Hb增加，同时伴有Oxy-Hb和Total-Hb增加，而9名（32.1%）受试者显示Deoxy-Hb减少。尽管Deoxy-Hb的变化方向不同，但这两组在Oxy-Hb和Total-Hb方面没有差异（P>0.05）。两名（7.1%）受试者显示出其他变化。新生儿的额叶显示出与视觉皮层中观察到的类似的CBO反应，具体而言，神经元激活会导致Deoxy-Hb增加，同时伴有Oxy-Hb和Total-Hb增加。这些结果支持了这样一种假设，即新生儿神经元活动期间氧气消耗的增加超过了氧气输送的增加。
