Chen Saying, Sakatani Kaoru, Lichty Wemara, Ning Pan, Zhao Shimin, Zuo Huancong
Department of Pediatrics, China-Japan Friendship Hospital, Hepingli, Beijing, China.
Early Hum Dev. 2002 Apr;67(1-2):113-21. doi: 10.1016/s0378-3782(02)00004-x.
Recent neuronal activation studies have demonstrated the presence of regional cerebral blood flow (rCBF) increases in response to neuronal activation in normal newborns. In the present study, using near infrared spectroscopy (NIRS), we evaluated the evoked cerebral blood oxygenation (CBO) changes in hypoxic-ischemic encephalopathy (HIE) of newborns. We studied 20 normal newborns and 22 HIE newborns; mild HIE (n=9), moderate HIE (n=7), and severe HIE (n=6). The babies were from 1 to 3 days postdelivery. We measured the concentration changes of deoxyhemoglobin (Deoxy-Hb), oxyhemoglobin (Oxy-Hb), and total hemoglobin (Total-Hb) induced by auditory stimulation in the frontal lobes. The normal and HIE groups showed different Oxy-Hb and Total-Hb responses. In normal newborns, 19 out of 20 normal subjects showed increases of Oxy-Hb and Total-Hb, whereas 14 out of 22 subjects showed decreases of Oxy-Hb and Total-Hb during the stimulation (chi(2)=19.95, p<0.001). In addition, there was a strong negative correlation between HIE severity and changes of Total-Hb (r=-0.73, p<0.001). These results suggest that infants with HIE have decreased rCBF in the frontal lobes during auditory stimulation.
近期的神经元激活研究表明，正常新生儿在神经元激活时会出现局部脑血流量（rCBF）增加。在本研究中，我们使用近红外光谱（NIRS）评估了新生儿缺氧缺血性脑病（HIE）中诱发的脑血氧合（CBO）变化。我们研究了20名正常新生儿和22名HIE新生儿；轻度HIE（n = 9）、中度HIE（n = 7）和重度HIE（n = 6）。这些婴儿出生后1至3天。我们测量了额叶听觉刺激诱发的脱氧血红蛋白（Deoxy-Hb）、氧合血红蛋白（Oxy-Hb）和总血红蛋白（Total-Hb）的浓度变化。正常组和HIE组表现出不同的Oxy-Hb和Total-Hb反应。在正常新生儿中，20名正常受试者中有19名在刺激期间Oxy-Hb和Total-Hb增加，而22名受试者中有14名在刺激期间Oxy-Hb和Total-Hb减少（χ2 = 19.95，p < 0.001）。此外，HIE严重程度与Total-Hb变化之间存在强烈的负相关（r = -0.73，p < 0.001）。这些结果表明，HIE婴儿在听觉刺激期间额叶的rCBF降低。
