Laezza F, Doherty J J, Dingledine R
Neuroscience Graduate Program, Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Science. 1999 Aug 27;285(5432):1411-4. doi: 10.1126/science.285.5432.1411.
Long-term depression (LTD) is a well-known form of synaptic plasticity of principal neurons in the mammalian brain. Whether such changes occur in interneurons is still controversial. CA3 hippocampal interneurons expressing Ca2+-permeable AMPA receptors exhibited LTD after tetanic stimulation of CA3 excitatory inputs. LTD was independent of NMDA receptors and required both Ca2+ influx through postsynaptic AMPA receptors and activation of presynaptic mGluR7-like receptors. These results point to the capability of interneurons to undergo plastic changes of synaptic strength through joint activation of pre- and postsynaptic glutamate receptors.
长时程抑制（LTD）是哺乳动物大脑中主要神经元突触可塑性的一种众所周知的形式。这种变化是否发生在中间神经元中仍存在争议。表达Ca2+通透型AMPA受体的CA3海马中间神经元在对CA3兴奋性输入进行强直刺激后表现出LTD。LTD与NMDA受体无关，需要通过突触后AMPA受体的Ca2+内流以及突触前mGluR7样受体的激活。这些结果表明，中间神经元有能力通过突触前和突触后谷氨酸受体的联合激活来经历突触强度的可塑性变化。
