钙通透型α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体在啮齿动物海马体主要神经元长时程增强中的作用
The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus.
作者信息
Park Pojeong, Kang Heather, Sanderson Thomas M, Bortolotto Zuner A, Georgiou John, Zhuo Min, Kaang Bong-Kiun, Collingridge Graham L
机构信息
Department of Biological Sciences and Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
出版信息
Front Synaptic Neurosci. 2018 Nov 22;10:42. doi: 10.3389/fnsyn.2018.00042. eCollection 2018.
Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic plasticity at these synapses. Here, we review this literature with a focus on recent evidence that CP-AMPARs are critical for the induction of the protein kinase A (PKA)- and protein synthesis-dependent component of LTP.
海马体CA1突触处的长时程增强（LTP）传统上是由NMDA受体（NMDARs）的突触激活触发的。最近的研究表明，钙通透（CP）型AMPA受体（AMPARs）也能在这些突触处触发突触可塑性。在此，我们回顾这一文献，重点关注CP-AMPARs对蛋白激酶A（PKA）和依赖蛋白合成的LTP成分诱导起关键作用的最新证据。
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